Hormones & weight loss....(which ones?)

Mar 09, 2025

Hormones & Weight loss - is it hype? What you actually need to know....

While I am still a HUGE believer in proper nutrition for weight loss - there definitely is a hormonal component at play.

When it comes to "hormones & weight loss" - there is a lot of vagueand confusing information out there. (I talked about this in Sunday's email -and how to decipher information - click here to read if you missed it).

There are also a lot of people who will tell you that you first need to work on adding in or "balancing" hormones like thyroid, estrogen - progesterone & testosterone....but there's a huge hugereason I almost never start there.

Today I want to give you the low down on 3 master hormones (and no - INSULIN is not included....and I will explain why) - and some free tips on how you can optimize them starting now!

Understanding the "Hormones & Weight loss" debate...

Now, I used to talk a lot about “hormone balancing.” But here’s the thing—I’ve shifted my perspective to focus on “hormone optimization.” Why? Because balance implies a static state, but optimization suggests that we’re actively working to get the most out of our hormones! And let's be real, no amount of supplements or quick fixes will really work if these three hormones aren’t optimized first.

Which hormones? Cortisol - Leptin & Melatonin...Let me explain!

Cortisol

Cortisol gets a lot of air time these days, but there IS a reason we need to consider it for weight loss & understand it from the lens of "optimization" - rather than "lowering" - here's why:

Cortisol is vital for several bodily functions, including regulating metabolism and immune response. However, consistently high levels of cortisol, often due to chronic stress, can have several negative impacts on weight loss:

  1. Increased Appetite: Elevated cortisol levels can stimulate appetite and cravings for high-calorie, sugary foods, making it easier to overeat.
  2. Fat Storage: High cortisol promotes fat storage, particularly visceral fat, which is associated with metabolic dysfunction and increased difficulty losing weight.
  3. Muscle Breakdown: Cortisol can lead to muscle catabolism, decreasing muscle mass, which in turn lowers your resting metabolic rate since muscle tissue burns more calories than fat.
  4. Thyroid Function Downgrade: Chronic elevated cortisol can inhibit the conversion of the thyroid hormone T4 into its more active form, T3, leading to reduced thyroid function. This slows metabolism and can further hinder weight loss efforts.

Optimizing for Balance

Rather than simply aiming to "lower" cortisol, focus on optimizing your levels. Click here to download my Cortisol Guide (it's free)

Leptin

Leptin is a key hormone in your weight loss journey, yet many overlook its significance. Rather than simply attempting to "lower" leptin levels, we should focus on "optimizing" them. Here’s why understanding leptin is crucial for effective weight management:

Leptin, known as the "satiety hormone," is produced by fat cells and helps regulate appetite and energy balance. However, various factors can lead to leptin resistance, causing the following issues:

  1. Diminished Satiety Signals: When leptin levels are high, they signal to your brain that you’re full. In leptin resistance, this signaling fails, leading to increased hunger and overeating.
  2. Increased Fat Storage: High insulin levels, often a result of poor diet and frequent snacking, can impair leptin’s effectiveness. This makes it harder for your body to signal when it needs to burn fat, leading to weight gain.
  3. Impact on Energy Levels: Leptin plays a role in regulating energy expenditure. When sensitivity is lost, it can slow your metabolism, making weight loss more challenging.
  4. Disruption of Other Hormones: Leptin resistance can negatively affect thyroid function, similar to cortisol issues. It can also lead to disturbances in other hormones that regulate hunger and metabolism, compounding weight loss difficulties.

How do you know you are leptin resistant?

Here are some common signs & symptoms that may indicate leptin resistance (you don't need to have all of them to qualify as leptin resistant):

  1. Increased Hunger: Frequent feelings of hunger or intense cravings, even after eating enough food, can suggest leptin resistance.
  2. Difficulty Losing Weight: Struggling to lose weight despite healthy eating and exercise often points to an issue with leptin signaling.
  3. Weight Gain: Unexplained weight gain, particularly around the abdomen, may indicate your body isn’t responding properly to leptin.
  4. Fatigue: Feeling unusually tired or low on energy, especially after meals, can reflect a struggle to utilize energy effectively due to leptin issues.
  5. Disrupted Sleep Patterns: Poor sleep quality or insomnia may be linked to dysfunctional leptin signaling.
  6. Increased Sugar Cravings: Strong desires for sugary or high-carbohydrate foods can indicate inadequate leptin signaling and satisfaction.
  7. High Levels of Stress: Chronic stress can elevate cortisol, contributing to leptin resistance and impairing appetite regulation.
  8. Thyroid Issues: Leptin resistance can negatively affect thyroid function, leading to symptoms like low energy and weight gain as your metabolism slows down.
  9. Immune System Dysfunction: Leptin plays a role in immune function, and resistance can lead to an imbalance in immune responses, making you more susceptible to illness.

Everyone points to INSULIN when it comes to weight loss, but Leptin actually signals the glucose/insulin axis, and working on reversing leptin resistance will directly improve insulin resistance.

Click here to take my Leptin Resistance Quiz

Melatonin - the missing link for many!

Melatonin is well-known for its role in regulating sleep, but it also plays a significant part in weight loss through several mechanisms:

  1. Sleep Quality: Melatonin promotes restful sleep, which is crucial for regulating appetite hormones like leptin and ghrelin. Poor sleep can lead to increased hunger and cravings, making weight loss more challenging.
  2. Metabolism Regulation: Melatonin enhances glucose metabolism and improves insulin sensitivity, aiding the body’s ability to utilize glucose for energy rather than storing it as fat.
  3. Antioxidant Effects: As a potent antioxidant, melatonin reduces oxidative stress, which is linked to metabolic disorders, potentially improving metabolic health and supporting weight loss.
  4. Fat Burning: Research suggests melatonin may promote the browning of white adipose tissue, encouraging fat burning and increasing overall energy expenditure.
  5. Circadian Rhythms: Melatonin influences circadian rhythms, making it important to align food intake with your body’s natural cycles to optimize leptin sensitivity.

Now let's put everything together ⬇️⬇️

Why we should always work to "optimize" rather than "lower"

When addressing hormone health for weight loss - longevity and overall health; particularly cortisol, leptin, and melatonin, the goal should always be to "optimize" rather than simply "lower." Here's why this approach is vital for achieving overall balance and wellness:

1. Understanding Function Over Reduction

Cortisol, leptin, and melatonin each play essential roles in our body's functioning. Cortisol helps regulate stress responses and metabolism, leptin signals satiety and energy expenditure, and melatonin controls sleep-wake cycles. Instead of aiming to reduce these hormones indiscriminately, we should focus on ensuring they function optimally within their natural rhythms (see chart above).

2. Balanced Cortisol Levels

Cortisol is crucial for managing stress and energy levels. While high cortisol can lead to issues like weight gain and fatigue, simply trying to lower it may lead to unwanted side effects such as low energy and poor stress management. Instead, optimizing cortisol levels through light hygiene, stress-reducing practices, proper sleep, and balanced nutrition can support its beneficial effects while mitigating excess.

3. Enhancing Leptin Sensitivity

Leptin controls hunger and metabolism. Rather than just targeting lower leptin levels, we should work on improving leptin sensitivity. This encourages better regulation of appetite and energy balance, making weight management more effective.

4. Promoting Healthy Melatonin Production

Melatonin is necessary for quality sleep and circadian rhythms. Focusing on optimizing melatonin levels—through good sleep hygiene practices and appropriate light exposure—will enhance sleep quality and metabolism.

Putting this all together involves a well rounded approach that controls for Light - Nutrition - Hydration & Stress Management. Stay tuned for more articles on this & if you are ready to get started today: This is what I have put together in my 21 Day Leptin Reset & The Leptin Master Plan (for practitioners).

Hope you enjoy the rest of your day, and please feel free to forward to a friend or family member who might find this interesting.

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